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Insights Into RNA Transcriptome Profiling of Cardiac Tissue in Obesity and Hypertension Conditions
Author(s) -
de Fátima Costa Alzenira,
Franco Octávio Luiz
Publication year - 2015
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24807
Subject(s) - transcriptome , gene expression , biology , gene expression profiling , rna seq , microarray , gene , bioinformatics , cardiac hypertrophy , microarray analysis techniques , muscle hypertrophy , computational biology , genetics , endocrinology
Several epidemiologic studies suggest that obesity and hypertension are associated with cardiac transcriptome modifications that could be further associated with inflammatory processes and cardiac hypertrophy. In this field, transcriptome studies have demonstrated their importance to elucidate physiologic mechanisms, pathways or genes involved in many biologic processes. Over the past decade, RNA microarray and RNA‐seq analysis has become an essential component to examine metabolic pathways in terms of mRNA expression in cardiology. In this review, cardiac muscle gene expression in response to effects of obesity and hypertension will be focused, providing a broad view on cardiac transcriptome and physiologic and biochemical mechanisms involved in gene expression changes produced by these events, emphasizing the use of new technologies for gene expression analyses. J. Cell. Physiol. 230: 959–968, 2015. © 2014 Wiley Periodicals, Inc., A Wiley Company