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Novel Insights Into TRPM7 Function in Fibrotic Diseases: A Potential Therapeutic Target
Author(s) -
Xu Tao,
Wu BaoMing,
Yao HongWei,
Meng XiaoMing,
Huang Cheng,
Ni MingMing,
Li Jun
Publication year - 2015
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24801
Subject(s) - trpm7 , transient receptor potential channel , endocytosis , microbiology and biotechnology , exocytosis , fibrosis , signal transduction , biology , pathogenesis , extracellular matrix , receptor , immunology , medicine , genetics , pathology , membrane
“Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of physical and chemical stimuli. Activation of TRP channels changes the membrane potential, translocates important signaling ions crossing the cell membrane, alters enzymatic activity, and initiates endocytosis/exocytosis (Zheng, 2013).” Fibrosis is the leading cause of organ dysfunction in diseases, which is characterized by an imbalance in the turnover of extracellular matrix components. Accumulating evidence has demonstrated that TRPM7, a member of TRP channels superfamily, participates in the development and pathogenesis of fibrotic diseases, such as hepatic, pulmonary and cardiac fibrosis. In this review, we discuss the comprehensive role of TRPM7 in modulating profibrotic response and its potential as therapeutic target for fibrotic diseases. J. Cell. Physiol. 230: 1163–1169, 2015. © 2014 Wiley Periodicals, Inc., A Wiley Company