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p16INK4a, NAD + , and Sestrins: New Targets for Combating Aging‐Related Chronic Illness?
Author(s) -
ParejaGaleano Helios,
SanchisGomar Fabian,
Lucia Alejandro
Publication year - 2014
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24627
Subject(s) - gerontology , chronic disease , nad+ kinase , medicine , psychology , intensive care medicine , biology , biochemistry , enzyme
Aging‐related chronic illness is a price we have to pay to live longer. Prevalent among the oldest old, the condition limits their functional independence and also aggravates the course of several age‐related chronic diseases. Thus, the search is on for efficient therapies that will mitigate age‐related pathologies. In this article, we point out the potential clinical implications of recent provocative basic research in the field. New possible targets have been recently discovered, are clearly involved in age‐related pathologies and might benefit the treatment of other age‐related conditions, particularly metabolic diseases. J. Cell. Physiol. 229: 1575–1576, 2014. © 2014 Wiley Periodicals, Inc.