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Induced Neural Lineage Cells as Repair Kits: So Close, Yet So Far Away
Author(s) -
Mirakhori Fahimeh,
Zeynali Bahman,
Salekdeh Ghasem Hosseini,
Baharvand Hossein
Publication year - 2014
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24509
Subject(s) - lineage (genetic) , cell lineage , evolutionary biology , biology , neural stem cell , microbiology and biotechnology , computational biology , neuroscience , genetics , cellular differentiation , gene , stem cell
Transdifferentiation or direct reprogramming of somatic cells into neural lineage cells has provided an invaluable new tool to advance the regenerative neural medicine. Here, we provide an overview of the various strategies currently available for producing of induced neural lineage cells in vitro as well as the direct reprogramming of neural cells in vivo. We also discussing some of the challenges faced in harnessing the potential of induced neural lineage cells for biomedical applications. J. Cell. Physiol. 229: 728–742, 2014. © 2013 Wiley Periodicals, Inc.