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The Pivotal Role of microRNA‐155 in the Control of Cancer
Author(s) -
Chen Zhaolin,
Ma Taotao,
Huang Cheng,
Hu Tingting,
Li Jun
Publication year - 2014
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24492
Subject(s) - microrna , gene silencing , oncogene , suppressor , biology , cancer , gene , cancer research , cell , rna interference , computational biology , cell growth , tumor suppressor gene , regulation of gene expression , microbiology and biotechnology , cell cycle , carcinogenesis , genetics , rna
microRNAs (miRNAs) are emerging as important gene expression regulators linked to various biological processes at a posttranscriptional level. miRNAs have been known to play important roles in cell proliferation, cell differentiation, and apoptosis. Recently, accumulate studies indicate that up‐regulation of miR‐155 has been described in several types of human tumors. miR‐155 has been considered to act as an oncogene or a tumor suppressor, depending on tumor system. Silencing oncomiRs or gene therapy approaches could be an effective therapeutic approach against tumor. Here we review the current knowledge on the functional role of miR‐155 in the control of various cancers. J. Cell. Physiol. 229: 545–550, 2014. © 2013 Wiley Periodicals, Inc.