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The Many Lives of CTIP2: From AIDS to Cancer and Cardiac Hypertrophy
Author(s) -
Le Douce Valentin,
Cherrier Thomas,
Riclet Raphael,
Rohr Olivier,
Schwartz Christian
Publication year - 2014
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24490
Subject(s) - regulator , cardiac hypertrophy , biology , medicine , muscle hypertrophy , genetics , gene
CTIP2 is a key transcriptional regulator involved in numerous physiological functions. Initial works have shown the importance of CTIP2 in the establishment and persistence of HIV latency in microglial cells, the main latent/quiescent viral reservoir in the brain. Recent studies have highlighted the importance of CTIP2 in several other pathologies, such as cardiac hypertrophy and various types of human malignancies. Targeting CTIP2 may therefore constitute a new approach in the treatment of these pathologies. J. Cell. Physiol. 229: 533–537, 2014. © 2013 Wiley Periodicals, Inc.