Modulation of TSC–mTOR Signaling on Immune Cells in Immunity and Autoimmunity | Zendy

Yang Hui | Zendy; Wang Xianghui | Zendy; Zhang Yan | Zendy; Liu Huanrong | Zendy; Liao Jiongbo | Zendy; Shao Kun | Zendy; Chu Yiwei | Zendy; Liu Guangwei | Zendy

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Modulation of TSC–mTOR Signaling on Immune Cells in Immunity and Autoimmunity

Author(s) -

Yang Hui,

Wang Xianghui,

Zhang Yan,

Liu Huanrong,

Liao Jiongbo,

Shao Kun,

Chu Yiwei,

Liu Guangwei

Publication year - 2014

Publication title -

journal of cellular physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 174

eISSN - 1097-4652

pISSN - 0021-9541

DOI - 10.1002/jcp.24426

Subject(s) - pi3k/akt/mtor pathway , tsc1 , immune system , microbiology and biotechnology , rptor , biology , mechanistic target of rapamycin , autoimmunity , acquired immune system , mtorc2 , regulator , signal transduction , t cell , mtorc1 , immunology , genetics , gene

The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase which has a central role in the regulation of cell growth and metabolism. In the study of the mTOR signaling pathway, tuberous sclerosis complex (TSC) 1/2 complex is identified as a critical regulator of mTOR activity. TSC1/2 plays important roles for immune cell homeostasis and differentiation by negative control of mTOR signaling pathway. TSC1/2–mTOR pathway is proving to be a central point in regulating immune function of diverse immune cells. In this review, we discuss the function of TSC1/2–mTOR to direct the innate and adaptive immune cell development and function. Furthermore, we focus on the role of TSC1/2–mTOR signaling pathway in immune cell mediated diseases, especially autoimmunity. J. Cell. Physiol. 229: 17–26, 2014. © 2013 Wiley Periodicals, Inc.

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