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Modulation of TSC–mTOR Signaling on Immune Cells in Immunity and Autoimmunity
Author(s) -
Yang Hui,
Wang Xianghui,
Zhang Yan,
Liu Huanrong,
Liao Jiongbo,
Shao Kun,
Chu Yiwei,
Liu Guangwei
Publication year - 2014
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24426
Subject(s) - pi3k/akt/mtor pathway , tsc1 , immune system , microbiology and biotechnology , rptor , biology , mechanistic target of rapamycin , autoimmunity , acquired immune system , mtorc2 , regulator , signal transduction , t cell , mtorc1 , immunology , genetics , gene
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase which has a central role in the regulation of cell growth and metabolism. In the study of the mTOR signaling pathway, tuberous sclerosis complex (TSC) 1/2 complex is identified as a critical regulator of mTOR activity. TSC1/2 plays important roles for immune cell homeostasis and differentiation by negative control of mTOR signaling pathway. TSC1/2–mTOR pathway is proving to be a central point in regulating immune function of diverse immune cells. In this review, we discuss the function of TSC1/2–mTOR to direct the innate and adaptive immune cell development and function. Furthermore, we focus on the role of TSC1/2–mTOR signaling pathway in immune cell mediated diseases, especially autoimmunity. J. Cell. Physiol. 229: 17–26, 2014. © 2013 Wiley Periodicals, Inc.