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PERIOSTIN: Role in Formation and Maintenance of Dental Tissues
Author(s) -
Romanos Georgios E.,
Asnani Ketkee P.,
Hingorani Dinesh,
Deshmukh Vijay L.
Publication year - 2014
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24407
Subject(s) - periostin , microbiology and biotechnology , chemistry , computational biology , biology , extracellular matrix
The matricellular protein periostin is strongly expressed in collagen‐rich connective tissues such as periodontal ligaments (PDLs), skeletal muscle, adipose tissue, tendons, skin, and bone. It is prominent in tumorigenesis, angiogenesis, and cardiac repair. It is localized in the periosteum and PDL, where it is seen in the cytoplasmic extensions of the PDL fibroblasts. It plays a key role in morphogenesis, postnatal development, and maintenance of the tooth, and related structures. It mediates and augments collagen fibrillogenesis, cell migration, adhesion, response to mechanical stress, and wound healing. It has been shown to be an integral regulator of periodontal disease pathogenesis and repair. This review focuses on the various functional aspects of periostin in dental connective tissue development and maintenance. J. Cell. Physiol. 229: 1–5, 2014. © 2013 Wiley Periodicals, Inc.