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Amyloid toxicity and platelet‐activating factor signaling
Author(s) -
Sirangelo Ivana,
Irace Gaetano,
Balestrieri Maria Luisa
Publication year - 2013
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24284
Subject(s) - amyloidosis , amyloid (mycology) , toxicity , platelet activating factor , mediator , cytotoxicity , neuroscience , platelet , microbiology and biotechnology , pharmacology , chemistry , biology , in vitro , biochemistry , immunology , medicine , pathology
Amyloidosis is the accumulation of insoluble proteinaceous aggregates in vivo and is implicated in many neurodegenerative diseases, including Alzheimer's, Huntington's, and Parkinson's diseases. This article briefly reviews the current knowledge of amyloid aggregate toxicity and inflammatory signaling in the nervous system. In particular, we focus our attention on the role of platelet‐activating factor (PAF) as mediator of amyloid cytotoxicity. J. Cell. Physiol. 228: 1143–1148, 2013. © 2012 Wiley Periodicals, Inc.