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The pur protein family: Genetic and structural features in development and disease
Author(s) -
Johnson Edward M.,
Daniel Dianne C.,
Gordon Jennifer
Publication year - 2013
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24237
Subject(s) - nucleic acid , biology , protein family , genetics , gene , dna binding protein , microbiology and biotechnology , computational biology , transcription factor
The Pur proteins are an ancient family of sequence‐specific single‐stranded nucleic acid‐binding proteins. They bind a G‐rich element in either single‐ or double‐stranded nucleic acids and are capable of displacing the complementary C‐rich strand. Recently several reports have described Pur family member knockouts, mutations, and disease aberrations. Together with a recent crystal structure of Purα, these data reveal conserved structural features of these proteins that have been adapted to serve functions unique to higher eukaryotes. In humans Pur proteins are critical for myeloid cell development, muscle development, and brain development, including trafficking of mRNA to neuronal dendrites. Pur family members have been implicated in diseases as diverse as cancer, premature aging, and fragile‐X mental retardation syndrome. J. Cell. Physiol. © 2013 Wiley Periodicals, Inc.