Premium
An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells
Author(s) -
Kim JungMin,
Choi Jin Seok,
Kim YunHee,
Jin Seong Hui,
Lim Seyoung,
Jang HyunJun,
Kim KyongTai,
Ryu Sung Ho,
Suh PannGhill
Publication year - 2013
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24171
Subject(s) - mesenchymal stem cell , creb , osteoblast , microbiology and biotechnology , teriparatide , cellular differentiation , regenerative medicine , activator (genetics) , chemistry , stem cell , biology , endocrinology , osteoporosis , transcription factor , receptor , bone mineral , in vitro , biochemistry , gene
Mesenchymal stem cells (MSCs) are multipotent adult stem cells capable of differentiating along the osteoblast, adipocyte, and chondrocyte lineages. Regulation of MSCs differentiation may be a useful tool for regenerative medicine and cell‐based therapy. The discovery of small molecule that activates the osteogenic differentiation of MSCs could aid in the development of a new anabolic drug for osteoporosis treatment. We identified CW008, a derivative of pyrazole–pyridine, that stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion. These results suggest that CW008 is an agonist of cAMP/PKA/CREB pathway in osteogenic differentiation and that application of CW008 may be useful for the treatment of bone‐related diseases and for the study of bone biology. J. Cell. Physiol. 228: 617–626, 2013. © 2012 Wiley Periodicals, Inc.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom