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The evolving field of induced pluripotency: Recent progress and future challenges
Author(s) -
Sommer Cesar A.,
Mostoslavsky Gustavo
Publication year - 2013
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24155
Subject(s) - induced pluripotent stem cell , drug discovery , regenerative medicine , somatic cell , computational biology , biology , embryonic stem cell , stem cell , bioinformatics , microbiology and biotechnology , genetics , gene
The derivation of patient‐specific pluripotent cell lines through the introduction of a few transcription factors into somatic cells has opened new avenues for the study and treatment of human disorders. Induced pluripotent stem cells (iPSCs) and their derivatives offer a unique platform for disease modeling, drug discovery and toxicology, as well as an invaluable source of cells for regenerative therapies. Here, we provide an overview of the various strategies currently available for iPSC generation, highlighting recent advances and discussing some of the challenges faced in harnessing the true potential of iPSCs for biomedical research and therapeutic applications. J. Cell. Physiol. 228: 267–275, 2013. © 2012 Wiley Periodicals, Inc.