Premium
Oxidases and reactive oxygen species during hematopoiesis: A focus on megakaryocytes
Author(s) -
Eliades Alexia,
Matsuura Shinobu,
Ravid Katya
Publication year - 2012
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24071
Subject(s) - haematopoiesis , reactive oxygen species , focus (optics) , microbiology and biotechnology , oxygen , megakaryocyte , biology , chemistry , biochemistry , stem cell , organic chemistry , physics , optics
Reactive oxygen species (ROS), generated as a result of various reactions, control an array of cellular processes. The role of ROS during megakaryocyte (MK) development has been a subject of interest and research. The bone marrow niche is a site of MK differentiation and maturation. In this environment, a gradient of oxygen tension, from normoxia to hypoxia results in different levels of ROS, impacting cellular physiology. This article provides an overview of major sources of ROS, their implication in different signaling pathways, and their effect on cellular physiology, with a focus on megakaryopoiesis. The importance of ROS‐generating oxidases in MK biology and pathology, including myelofibrosis, is also described. J. Cell. Physiol. 227: 3355–3362, 2012. © 2012 Wiley Periodicals, Inc.