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New insights in endometrial carcinogenesis
Author(s) -
D'Andrilli Giuseppina,
Bovicelli Alessandro,
Paggi Marco G.,
Giordano Antonio
Publication year - 2012
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.24016
Subject(s) - carcinogenesis , endometrial cancer , pathogenesis , cancer research , endometrial hyperplasia , carcinoma , biology , hyperplasia , disease , oncology , medicine , cancer
Endometrial carcinoma is the most common cancer of the female genital tract in Europe and in the United States. Despite advances in defining the biology of endometrial carcinomas, there has been poor progress in determining markers that distinguish preinvasive endometrial proliferations. The aim of this review is to highlight the most recent studies regarding the molecular markers involved in endometrial adenocarcinoma pathogenesis and carcinogenesis. We focus on studies that describe markers with potential to progress from endometrial hyperplasia to invasive disease. J. Cell. Physiol. 227: 2842–2846, 2012. © 2011 Wiley Periodicals, Inc.