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Crosstalk between mitochondrial (dys)function and mitochondrial abundance
Author(s) -
Michel Sébastien,
Wanet Anaïs,
De Pauw Aurélia,
Rommelaere Guillaume,
Arnould Thierry,
Renard Patricia
Publication year - 2012
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.23021
Subject(s) - mitochondrial biogenesis , mitophagy , microbiology and biotechnology , mitochondrion , crosstalk , biology , biogenesis , mitochondrial fusion , dnaja3 , organelle , organelle biogenesis , autophagy , mitochondrial dna , biochemistry , apoptosis , gene , physics , optics
Abstract A controlled regulation of mitochondrial mass through either the production (biogenesis) or the degradation (mitochondrial quality control) of the organelle represents a crucial step for proper mitochondrial and cell function. Key steps of mitochondrial biogenesis and quality control are overviewed, with an emphasis on the role of mitochondrial chaperones and proteases that keep mitochondria fully functional, provided the mitochondrial activity impairment is not excessive. In this case, the whole organelle is degraded by mitochondrial autophagy or “mitophagy.” Beside the maintenance of adequate mitochondrial abundance and functions for cell homeostasis, mitochondrial biogenesis might be enhanced, through discussed signaling pathways, in response to various physiological stimuli, like contractile activity, exposure to low temperatures, caloric restriction, and stem cells differentiation. In addition, mitochondrial dysfunction might also initiate a retrograde response, enabling cell adaptation through increased mitochondrial biogenesis. J. Cell. Physiol. 227: 2297–2310, 2012. © 2011 Wiley Periodicals, Inc.