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MicroRNAs in the midst of myeloid signal transduction
Author(s) -
Stoffers Sara L.,
Meyer Sara E.,
Grimes H. Leighton
Publication year - 2012
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22823
Subject(s) - myelopoiesis , microrna , myeloid leukemia , signal transduction , biology , haematopoiesis , myeloid , function (biology) , progenitor cell , microbiology and biotechnology , cancer research , stem cell , gene , genetics
MicroRNA (miRNA) play important roles in the development and physiological function of hematopoietic stem/progenitor and mature cell lineages. In addition, deregulated miRNA expression and subsequent gene expression changes are associated with hematologic diseases including myelodysplastic syndromes and acute myeloid leukemia. This review focuses on myelopoiesis as a model to highlight the involvement of miRNA in the regulation of normal and malignant cellular signaling pathways. By incorporating miRNA regulation into well‐established myeloid signal transduction pathways, we hope to shed light on targetable factors both upstream and downstream of miRNA signaling. These pathway‐specific miRNA functions suggest scenarios wherein miRNA‐based therapeutics may be beneficial either alone or in combination with current therapies. J. Cell. Physiol. 227: 525–533, 2012. © 2011 Wiley Periodicals, Inc.