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High expression of ubiquitin conjugates and NF‐κB in unstable human intracranial atherosclerotic plaques
Author(s) -
Sun Ruihong,
Xiao Ling,
Duan Shurong
Publication year - 2012
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22790
Subject(s) - ubiquitin , nf κb , pathology , conjugate , cerebral arteries , immunohistochemistry , chemistry , biology , medicine , anatomy , apoptosis , biochemistry , gene , mathematical analysis , mathematics
Arteries from the first segment of the middle cerebral and adjacent normal blood vessel specimens were collected from 19 patients who had died from cerebral infarction. According to morphologic examination the atherosclerotic plaque present was classified as stable or unstable. The expression of ubiquitin conjugates and nuclear factor kappa B (NF‐κB) was assessed and found significantly higher in plaques than normal tissue and higher in unstable plaques than in stable plaques. Ubiquitin conjugates and NF‐κB were positively correlated with each other. It was concluded that the ubiquitin proteasome system and NF‐κB possibly play a role in the development of atherosclerotic plaques in intracranial arteries. J. Cell. Physiol. 227: 784–788, 2012. © 2011 Wiley Periodicals, Inc.