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The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence
Author(s) -
Helmbold Heike,
Galderisi Umberto,
Bohn Wolfgang
Publication year - 2012
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22786
Subject(s) - senescence , dna damage , retinoblastoma protein , microbiology and biotechnology , retinoblastoma , cell cycle checkpoint , cellular senescence , biology , cell cycle , dna , cell , genetics , gene , phenotype
Cellular senescence is a response to genotoxic stress that results in an irreversible cell cycle arrest. Activation of this pathway relies on the activity of the retinoblastoma proteins and proteins of the DNA damage response cascade. Here, we discuss the functional relevance of the switch from pRb/p105 to Rb2/p130 that becomes apparent when cells enter senescent arrest. J. Cell. Physiol. 227: 508–513, 2012. © 2011 Wiley Periodicals, Inc.