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Emerging strategies for the early detection and prevention of head and neck squamous cell cancer
Author(s) -
Dasgupta Santanu,
Dash Rupesh,
Das Swadesh K.,
Sarkar Devanand,
Fisher Paul B.
Publication year - 2012
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22767
Subject(s) - squamous cell cancer , head and neck cancer , head and neck , cancer , head and neck squamous cell carcinoma , medicine , cell , oncology , cancer research , biology , genetics , surgery
Despite significant improvements in therapeutic protocols, head and neck squamous cell carcinoma (HNSCC) remains a major health problem worldwide. The 5‐year post‐therapeutic survival rate is among the lowest of the major cancers with loco‐regional relapse being the main cause of death. Moreover, in most instances, the quality of life of the afflicted patient is severely compromised. The poor prognosis for HNSCC is primarily due to disease detection at advanced stages. Accordingly, development of early detection and preventive strategies are essential. Recent advances in our understanding of the molecular biology and etiology of HNSCC should facilitate development of improved intervention and therapeutic approaches. The present review discusses the potential role of such factors for developing preventive and early diagnostic strategies for HNSCC management. J. Cell. Physiol. 227: 467–473, 2012. © 2011 Wiley Periodicals, Inc.