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MicroRNAs: Allies or Foes in erythropoiesis?
Author(s) -
Byon John C.H.,
Papayannopoulou Thalia
Publication year - 2012
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22729
Subject(s) - erythropoiesis , microrna , ineffective erythropoiesis , political science , biology , microbiology and biotechnology , genetics , medicine , gene , anemia
MicroRNAs are small non‐coding RNAs that negatively regulate gene expression through mRNA degradation or translational repression. It is becoming increasingly recognized that miRNAs play central roles in almost all cellular processes, and especially during development. The function of miRNAs in hematopoiesis, including erythropoiesis, is beginning to be elucidated. In this review, we will focus on what is known about miRNA function in various aspects of erythropoiesis and red cell physiology. J. Cell. Physiol. 227: 7–13, 2012. © 2011 Wiley Periodicals, Inc.