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Recent advances in X‐chromosome inactivation
Author(s) -
Kalantry Sundeep
Publication year - 2011
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22673
Subject(s) - epigenetics , x inactivation , biology , genetics , embryonic stem cell , chromosome , x chromosome , gene , disease , dosage compensation , medicine , pathology
X‐chromosome inactivation is a paradigmatic epigenetic phenomenon that results in the mitotically heritable transcriptional inactivation of one X‐chromosome in female mammals, thereby equalizing X‐linked gene dosage between the sexes. The epigenetic factors and mechanisms that execute X‐inactivation overlap with those that regulate embryonic development and disease progression, thus offering a window into the epigenetic processes that regulate development and disease. Here I summarize some recent developments as well as open questions in X‐inactivation research. J. Cell. Physiol. 226: 1714–1718, 2011. © 2011 Wiley‐Liss, Inc.