Premium
New players in ovarian cancer
Author(s) -
Bovicelli Alessandro,
D'Andrilli Giuseppina,
Giordano Antonio
Publication year - 2011
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22662
Subject(s) - ovarian cancer , disease , carcinogenesis , microrna , cancer , medicine , histone deacetylase , oncology , cancer research , bioinformatics , biology , histone , gene , genetics
Ovarian cancer is the leading cause of gynecologic cancer mortality worldwide. The aim of this review is to highlight the most recent studies regarding ovarian cancer pathogenesis and the new therapeutic approaches against this insidious disease. We focus on the relevance of some cell cycle genes, transcription factors, and microRNAs in the carcinogenesis of ovarian cancer as well as on a new hypothesis for therapy using histone deacetylase inhibitors. We also report recent studies regarding some mechanisms of chemoresistance, a major obstacle in the treatment of ovarian cancer. Together these studies can improve our knowledge of ovarian cancer tumorigenesis and diagnosis providing new tools to hopefully defeat this deadly disease. J. Cell. Physiol. 226: 2500–2504, 2011. © 2011 Wiley‐Liss, Inc.