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Growth factors controlling ovarian functions
Author(s) -
Sirotkin Alexander V.
Publication year - 2011
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22588
Subject(s) - biology , growth factor , epidermal growth factor , oogenesis , folliculogenesis , cell growth , microbiology and biotechnology , wnt signaling pathway , vascular endothelial growth factor , medicine , endocrinology , hormone , cancer research , oocyte , vegf receptors , signal transduction , embryogenesis , genetics , cell culture , embryo , receptor
The present review demonstrates an important role of different growth factors (of insulin‐like growth factors, epidermal growth factors, vascular endothelial growth factor, thrombopoietin, erytropoietin, hepatocyte growth factor, and growth factors of Hedgehog, Wnt and Notch families) in control of different ovarian functions—ovarian cell proliferation, apoptosis, folliculogenesis, luteogenesis, oogenesis, release of hormones, response to upstream hormonal regulators, fertility and, in some cases, in development of ovarian disorders. The possibility of practical application of these growth factors for characterization, prediction, and regulation the ovarian state is demonstrated. J. Cell. Physiol. 226: 2222–2225, 2011. © 2010 Wiley‐Liss, Inc.