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Physiological implications of adenosine receptor‐mediated platelet aggregation
Author(s) -
JohnstonCox Hillary A.,
Yang Dan,
Ravid Katya
Publication year - 2011
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22379
Subject(s) - adenosine , receptor , platelet , adenosine diphosphate , adenosine receptor , intracellular , chemistry , cyclic adenosine monophosphate , adenosine a2b receptor , adenosine a1 receptor , biochemistry , microbiology and biotechnology , mediator , platelet activation , pharmacology , biology , platelet aggregation , agonist , immunology
Adenosine is an important mediator of inhibition of platelet activation. This metabolite is released from various cells, as well as generated via activity of ecto‐enzymes on the cell surface. Binding of adenosine to A 2 subtypes (A 2A or A 2B ), G‐protein coupled adenosine receptors, results in increased levels of intracellular cyclic adenosine monophosphate (cAMP), a strong inhibitor of platelet activation. The role and importance of adenosine and its receptors in platelet physiology are addressed in this review, including recently identified roles for the A 2B adenosine receptor as a modulator of platelet activation through its newly described role in the control of expression of adenosine diphosphate (ADP) receptors. J. Cell. Physiol. 226: 46–51, 2010. © 2010 Wiley‐Liss, Inc.