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Origin of cardiac progenitor cells in the developing and postnatal heart
Author(s) -
Kuhn Elizabeth N.,
Wu Sean M.
Publication year - 2010
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22281
Subject(s) - progenitor cell , medicine , progenitor , cardiology , microbiology and biotechnology , heart development , biology , stem cell , genetics , embryonic stem cell , gene
The mammalian heart lacks the capacity to replace the large numbers of cardiomyocytes lost due to cardiac injury. Several different cell‐based routes to myocardial regeneration have been explored, including transplantation of cardiac progenitors and cardiomyocytes into injured myocardium. As seen with cell‐based therapies in other solid organ systems, inherent limitations, such as host immune response, cell death and long‐term graft instability have hampered meaningful cardiac regeneration. An understanding of the cell biology of cardiac progenitors, including their developmental origin, lineage markers, renewal pathways, differentiation triggers, microenvironmental niche, and mechanisms of homing and migration to the site of injury, will enable further refinement of therapeutic strategies to enhance clinically meaningful cardiac repair. J. Cell. Physiol. 225: 321–325, 2010. © 2010 Wiley‐Liss, Inc.