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RNA interference and ovarian functions
Author(s) -
Sirotkin Alexander V.
Publication year - 2010
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22277
Subject(s) - rna interference , dna directed rna interference , rna , biology , microrna , ovarian cancer , oocyte , small rna , gene expression , cell , computational biology , microbiology and biotechnology , gene , cancer , genetics , embryo
RNA interference, a recently discovered new mechanism controlling gene expression via small RNAs, was shown to be involved in characterization and control of basic ovarian cell functions. The main classes of small RNAs, as well as their expression in ovaries have been described. Furthermore, the successful application of RNA interference for study and control of basic ovarian functions (proliferation, apoptosis, secretory activity, luteogenesis, oocyte maturation, and related ovarian cell malignant transformation) and production of recombinant proteins have been demonstrated. Application of RNA interference in reproductive biology and medicine can be successful in two main areas: (1) characterization and prediction of physiological and pathological state (association between particular small RNA and physiological or pathological processes), (2) application of small RNAs for regulation of reproductive processes and treatment of reproductive disorders or their particular indexes. Problems of improvement of small RNA delivery to target ovarian cells and potent RNA interference‐related approaches for treatment of ovarian disorders (especially of ovarian cancer) have been discussed. J. Cell. Physiol. 225: 354–363, 2010. © 2010 Wiley‐Liss, Inc.