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Transcription factors and ovarian functions
Author(s) -
Sirotkin Alexander V.
Publication year - 2010
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22248
Subject(s) - transcription factor , follicular phase , biology , tcf4 , e box , transcription (linguistics) , ets transcription factor family , ovulation , taf2 , oocyte , cancer research , hormone , microbiology and biotechnology , endocrinology , gene , genetics , embryo , linguistics , philosophy , enhancer
This study represents a first review of contemporarily knowledge concerning involvement of transcription factors in control of different ovarian functions. After introduction of basic functions and classification of transcription factors, the available data concerning involvement of transcription factors in control of the following ovarian events are present: follicular development and selection, ovarian cell proliferation and cancerogenesis, ovarian cell apoptosis, ovarian secretory activity, oocyte/cumulus maturation, ovulation and luteogenesis, mediation effect of hormones, growth factors, and cytokines. The importance of transcription factors of Smad family, of forkhead transcription factor (Fox) family, of breast cancer‐associated genes/transcription factor, hypoxia‐induced transcription factors and of other transcription factors in control of these processes has been demonstrated. J. Cell. Physiol. 225: 20–26, 2010. © 2010 Wiley‐Liss, Inc.