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Navigating the nucleotide excision repair threshold
Author(s) -
Liu Liren,
Lee Jennifer,
Zhou Pengbo
Publication year - 2010
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22205
Subject(s) - nucleotide excision repair , dna repair , dna damage , dna , biology , base excision repair , microbiology and biotechnology , genetics , chemistry , computational biology
Nucleotide excision repair (NER) is the primary DNA repair pathway that removes helix‐distorting DNA strand damage induced by ultraviolet light irradiation or chemical carcinogens to ensure genome integrity. While the core NER proteins that carry out damage recognition, excision, and repair reactions have been identified and extensively characterized, and the NER pathway has been reconstituted in vitro, the regulatory pathways that govern the threshold levels of NER have not been fully elucidated. This mini‐review focuses on recently discovered transcriptional and post‐translational mechanisms that specify the capacity of NER, and suggests the potential implications of modulating NER activity in cancer prevention and therapeutic intervention. J. Cell. Physiol. 224: 585–589, 2010. © 2010 Wiley‐Liss, Inc.