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Meiotic cell cycle arrest in mammalian oocytes
Author(s) -
Tripathi Anima,
Kumar K.V. Prem,
Chaube Shail K.
Publication year - 2010
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22108
Subject(s) - microbiology and biotechnology , oocyte , metaphase , cell cycle checkpoint , protein kinase a , biology , meiosis , maturation promoting factor , cyclin dependent kinase 1 , cell cycle , kinase , chemistry , cell , biochemistry , embryo , chromosome , gene
Meiotic cell cycle in mammalian oocytes is a dynamic process that involves several stop/go channels. The cell cycle arrest in oocyte occurs at various stages such as diplotene, metaphase‐I (M‐I), metaphase‐II (M‐II), and so called metaphase‐like arrest (M‐III). Leutinizing hormone surge induces meiotic resumption from diplotene arrest in follicular microenvironment by overriding several factors responsible for the maintenance of meiotic arrest. The inhibitory factors are synthesized in oocyte or in the associated follicular somatic cells and transferred to the oocyte. The major factors include hypoxanthine, cyclic adenosine 3′, 5′‐monophosphate, cyclic guanosine 3′, 5′‐monophosphate, reactive oxygen species, protein kinase A, and protein kinase C. In the presence of active protein kinases, epidermal‐like growth factors are produced that activate mitogen‐activated protein kinase in cumulus granulosa cells. The maturation promoting factor, cytostatic factors, and spindle assembly checkpoint proteins are also involved in that maintenance of arrest at various stages of meiotic cell cycle in mammalian oocytes. In this review, we briefly summarize the role of these factors in the maintenance of meiotic cell cycle arrest in mammalian oocytes. J. Cell. Physiol. 223:592–600, 2010. © 2010 Wiley‐Liss, Inc.