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Curcumin stimulates glucose uptake through AMPK‐p38 MAPK pathways in L6 myotube cells
Author(s) -
Kim Ji Hae,
Park Ji Man,
Kim EungKyun,
Lee Jung Ok,
Lee Soo Kyung,
Jung Jin Hee,
You Ga Young,
Park Sun Hwa,
Suh PannGhill,
Kim Hyeon Soo
Publication year - 2010
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.22093
Subject(s) - curcumin , ampk , protein kinase a , p38 mitogen activated protein kinases , mapk/erk pathway , amp activated protein kinase , chemistry , microbiology and biotechnology , kinase , skeletal muscle , biology , endocrinology , biochemistry
Curcumin has been shown to exert a variety of beneficial human health effects. However, mechanisms by which curcumin acts are poorly understood. In this study, we report that curcumin activated AMP‐activated protein kinase (AMPK) and increased glucose uptake in rat L6 myotubes. In addition, curcumin activated the mitogen‐activated protein kinase kinase (MEK)3/6‐p38 mitogen‐activated protein kinase (MAPK) signaling pathways in the downstream of the AMPK cascade. Moreover, inhibition of either AMPK or p38 MAPK resulted in blockage of curcumin‐induced glucose uptake. Furthermore, the administration of curcumin to mice increased AMPK phosphorylation in the skeletal muscles. Taken together, these results indicate that the beneficial health effect of curcumin can be explained by its ability to activate AMPK‐p38 MAPK pathways in skeletal muscles. J. Cell. Physiol. 223:771–778, 2010. © 2010 Wiley‐Liss, Inc.