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Notch signalling and haematopoietic stem cell formation during embryogenesis
Author(s) -
Gering Martin,
Patient Roger
Publication year - 2010
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21905
Subject(s) - embryonic stem cell , haematopoiesis , microbiology and biotechnology , stem cell , notch signaling pathway , progenitor cell , biology , context (archaeology) , cell fate determination , embryogenesis , neuroscience , immunology , signal transduction , embryo , genetics , gene , paleontology , transcription factor
The Notch signalling pathway is repeatedly employed during embryonic development and adult homeostasis of a variety of tissues. In particular, its frequent involvement in the regulation of stem and progenitor cell maintenance and proliferation, as well as its role in binary fate decisions in cells that are destined to differentiate, is remarkable. Here, we review its role in the development of haematopoietic stem cells during vertebrate embryogenesis and put it into the context of Notch's functions in arterial specification, angiogenic vessel sprouting and vessel maintenance. We further discuss interactions with other signalling cascades, and pinpoint open questions and some of the challenges that lie ahead. J. Cell. Physiol. 222:11–16, 2010. © 2009 Wiley‐Liss, Inc.