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Cell based therapy for duchenne muscular dystrophy
Author(s) -
Farini Andrea,
Razini Paola,
Erratico Silvia,
Torrente Yvan,
Meregalli Mirella
Publication year - 2009
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21895
Subject(s) - duchenne muscular dystrophy , muscular dystrophy , dystrophin , stem cell , genetic enhancement , cell therapy , population , cell , stem cell therapy , regeneration (biology) , medicine , bioinformatics , biology , gene , genetics , environmental health
Mutations in the dystrophin gene cause an X‐linked genetic disorder: Duchenne muscular dystrophy (DMD). Stem cell therapy is an attractive method to treat DMD because a small number of cells are required to obtain a therapeutic effect. Here, we discussed about multiple types of myogenic stem cells and their possible use to treat DMD. The identification of a stem cell population providing efficient muscle regeneration is critical for the progression of cell therapy for DMD. We speculated that the most promising possibility for the treatment of DMD is a combination of different approaches, such as gene and stem cell therapy. J. Cell. Physiol. 221: 526–534, 2009. © 2009 Wiley‐Liss, Inc.