Cell based therapy for duchenne muscular dystrophy | Zendy

Farini Andrea | Zendy; Razini Paola | Zendy; Erratico Silvia | Zendy; Torrente Yvan | Zendy; Meregalli Mirella | Zendy

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Cell based therapy for duchenne muscular dystrophy

Author(s) -

Farini Andrea,

Razini Paola,

Erratico Silvia,

Torrente Yvan,

Meregalli Mirella

Publication year - 2009

Publication title -

journal of cellular physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 174

eISSN - 1097-4652

pISSN - 0021-9541

DOI - 10.1002/jcp.21895

Subject(s) - duchenne muscular dystrophy , muscular dystrophy , dystrophin , stem cell , genetic enhancement , cell therapy , population , cell , stem cell therapy , regeneration (biology) , medicine , bioinformatics , biology , gene , genetics , environmental health

Mutations in the dystrophin gene cause an X‐linked genetic disorder: Duchenne muscular dystrophy (DMD). Stem cell therapy is an attractive method to treat DMD because a small number of cells are required to obtain a therapeutic effect. Here, we discussed about multiple types of myogenic stem cells and their possible use to treat DMD. The identification of a stem cell population providing efficient muscle regeneration is critical for the progression of cell therapy for DMD. We speculated that the most promising possibility for the treatment of DMD is a combination of different approaches, such as gene and stem cell therapy. J. Cell. Physiol. 221: 526–534, 2009. © 2009 Wiley‐Liss, Inc.

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