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Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. γ‐tubulin
Author(s) -
Katsetos Christos D.,
Dráberová Eduarda,
Legido Agustin,
Dráber Pavel
Publication year - 2009
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21884
Subject(s) - carcinogenesis , tubulin , biology , brain tumor , glioblastoma , cancer , glioma , cancer research , microtubule , mitosis , oligodendroglial tumor , compartmentalization (fire protection) , oligodendroglioma , pathology , medicine , microbiology and biotechnology , genetics , astrocytoma , biochemistry , enzyme
Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain cancer in adults. Despite advances in molecular biology and genetics of cancer there is no currently available treatment for these tumors. Aberrant patterns of γ‐tubulin expression and compartmentalization in GBM have been reported lending credence to the assertion that these changes might underlie perturbations in microtubule nucleation and mitosis associated with glioma tumorigenesis and tumor progression. This minireview focuses on the role of γ‐tubulin in the pathobiology of GBM in the light of emerging concepts concerning the function of γ‐tubulin and its potential role in tumorigenesis putting forward the concept that γ‐tubulin might serve as a novel marker of anaplastic change in gliomas. J. Cell. Physiol. 221: 514–520, 2009. © 2009 Wiley‐Liss, Inc.