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NAG7 promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up‐regulation of JNK2/AP‐1/MMP1 pathways
Author(s) -
Huang Chen,
Wu Minghua,
Tang Yunlian,
Li Xiaoling,
Ouyang Jue,
Xiao Lan,
Li Dan,
Li Guiyuan
Publication year - 2009
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21867
Subject(s) - nasopharyngeal carcinoma , cancer research , biology , estrogen receptor , regulator , estrogen , signal transduction , mmp1 , receptor , microbiology and biotechnology , medicine , endocrinology , gene expression , cancer , biochemistry , gene , genetics , breast cancer , radiation therapy
The NAG7 , an estrogen receptor repressor, is a negative regulator of nasopharyngeal carcinoma cell growth. Here, we report that NAG7 promotes human nasopharyngeal carcinoma invasion, and we identify the mechanisms underlying this function. As a consequence of elevated NAG7 expression, the adhesion, migration, and invasive capabilities of HNE1 cells in vitro and in vivo were enhanced. NAG7 was a significant negative regulator of protein expression of estrogen receptor alpha (ERα), and activated both the JNK2/AP‐1/MMP1 and the upstream H‐Ras/p‐c‐Raf pathways. None of these effects induced by NAG7 over‐expression could be counteracted by estrogen. These observations indicate that NAG7 plays a potential role in promoting nasopharyngeal carcinoma invasion by regulation of ERα and the H‐ras/p‐c‐Raf and JNK2/AP‐1/MMP1 signaling pathways. J. Cell. Physiol. 221: 394–401, 2009. © 2009 Wiley‐Liss, Inc.