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Chromatin remodeling in Embryonic stem cells: Regulating the balance between pluripotency and differentiation
Author(s) -
Keenen Bridget,
de la Serna Ivana L.
Publication year - 2009
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21654
Subject(s) - embryonic stem cell , microbiology and biotechnology , biology , induced pluripotent stem cell , chromatin , cell potency , epigenetics , cellular differentiation , stem cell , chromatin remodeling , reprogramming , bivalent chromatin , somatic cell , cell , genetics , gene
Embryonic stem cells have an unlimited potential for self‐renewal yet are pluripotent, capable of differentiating into three different germ layers and ultimately into multiple cell lineages. Key pluripotency specific factors maintain an undifferentiated ES cell phenotype while lineage specific factors work in opposition to promote cell specialization. In addition to these important transcriptional regulators, epigenetic modifiers play a defining role in regulating the balance between pluripotency and differentiation by promoting changes in chromatin structure. J. Cell. Physiol. 219: 1–7, 2009. © 2008 Wiley‐Liss, Inc.