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Human embryonic stem cells and cardiac cell fate
Author(s) -
Nury David,
Neri Tui,
Pucéat Michel
Publication year - 2009
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21631
Subject(s) - embryonic stem cell , lineage (genetic) , biology , induced pluripotent stem cell , stem cell , cell lineage , cell fate determination , microbiology and biotechnology , cellular differentiation , cell , genetics , gene , transcription factor
Human embryonic stem (HES) cells are pluripotent and give rise to any cell lineage. More specifically, how the first embryonic lineage (i.e., cardiac lineage) is acquired remains in many aspects questionable. Herein, we summarize the protocols that have been used to direct the fate of HES cells toward the cardiomyocytic lineage. We further discuss the regulation of transcriptional pathways underlying this process of differentiation. Finally, we propose perspectives of this research in the near future. J. Cell. Physiol. 218: 455–459, 2009. © 2008 Wiley‐Liss, Inc.