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Metastasis and AKT activation
Author(s) -
Sheng Shijie,
Qiao Meng,
Pardee Arthur B.
Publication year - 2009
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21616
Subject(s) - protein kinase b , metastasis , cancer research , cancer , medicine , cancer metastasis , pi3k/akt/mtor pathway , oncology , biology , signal transduction , microbiology and biotechnology
Metastasis, responsible for 90% of cancer patient deaths, is an inefficient process because many tumor cells die. The survival of metastatic tumor cells should be considered as a critical therapeutic target. This review provides a new perspective regarding the role of AKT in tumor survival, and the rationale to target AKT in anti‐metastasis therapies. J. Cell. Physiol. 218: 451–454, 2009. © 2008 Wiley‐Liss, Inc.