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The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair
Author(s) -
Arthur Agnieszka,
Zannettino Andrew,
Gronthos Stan
Publication year - 2009
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21592
Subject(s) - mesenchymal stem cell , clinical uses of mesenchymal stem cells , stem cell , microbiology and biotechnology , stromal cell , stem cell transplantation for articular cartilage repair , regenerative medicine , paracrine signalling , bone marrow , biology , adult stem cell , immunology , cellular differentiation , cancer research , biochemistry , receptor , gene
Four decades after the first isolation and characterization of clonogenic bone marrow stromal cells or mesenchymal stem cells (MSC) in the laboratory of Dr. Alexander Friedenstien, the therapeutic application of their progeny following ex vivo expansion are only now starting to be realized in the clinic. The multipotency, paracrine effects, and immune‐modulatory properties of MSC present them as an ideal stem cell candidate for tissue engineering and regenerative medicine. In recent years it has come to light that MSC encompass plasticity that extends beyond the conventional bone, adipose, cartilage, and other skeletal structures, and has expanded to the differentiation of liver, kidney, muscle, skin, neural, and cardiac cell lineages. This review will specifically focus on the skeletal regenerative capacity of bone marrow derived MSC alone or in combination with growth factors, biocompatible scaffolds, and following genetic modification. J. Cell. Physiol. 218: 237–245, 2009. © 2008 Wiley‐Liss, Inc.