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Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling?
Author(s) -
Rodeck Ulrich
Publication year - 2009
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21585
Subject(s) - hair follicle , epidermal growth factor receptor , egfr inhibitors , inflammation , cancer research , blockade , signal transduction , receptor , biology , medicine , immunology , microbiology and biotechnology
Acneiform skin eruptions associated with sterile inflammation frequently accompany pharmacological inhibition of signaling through the epidermal growth factor receptor (EGFR) in cancer patients. Here we discuss possible pathogenic mechanisms for this phenomenon linked to control of inflammatory mediators by EGFR blockade in keratinocytes of the outer root sheath of the hair follicle. This discussion is focused on the putative role of EGFR activation in restraining interleukin (IL)‐1‐dependent inflammatory networks at the hair follicle. J. Cell. Physiol. 218: 32–34, 2009. © 2008 Wiley‐Liss, Inc.