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Treatment of pediatric brain tumors
Author(s) -
Karajannis Matthias,
Allen Jeffrey C.,
Newcomb Elizabeth W.
Publication year - 2008
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21544
Subject(s) - medulloblastoma , radiation therapy , medicine , neurosurgery , brain tumor , chemotherapy , oncology , bioinformatics , pathology , biology , surgery
Over the past decades considerable advances have been made in neurosurgery, radiotherapy and chemotherapy resulting in improved survival and cure rates for children with brain tumors. Here we review four of the most common subtypes of pediatric brain tumors, low‐grade and high‐grade astrocytomas, medulloblastomas and ependymomas, highlighting their molecular features regarding their tumor biology, and promising potential therapeutic targets that may hold promise for finding new “molecular targeted” drugs. Importantly, appropriate clinical trial design will play a critical role in the evaluation of new and novel treatment approaches for pediatric brain tumors. J. Cell. Physiol. 217: 584–589, 2008. © 2008 Wiley‐Liss, Inc.