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Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals
Author(s) -
Duverger Olivier,
Morasso Maria I.
Publication year - 2008
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21491
Subject(s) - homeobox , homeobox a1 , dlx5 , biology , appendage , homeobox protein nkx 2.5 , hnf1b , transcription factor , gene , developmental biology , genetics , function (biology) , microbiology and biotechnology , anatomy
Homeobox genes are an evolutionarily conserved class of transcription factors that are key regulators during developmental processes such as regional specification, patterning, and differentiation. In this review, we summarize the expression pattern, loss‐ and/or gain‐of‐function mouse models, and naturally occurring mouse and human mutations of known homeobox genes required for the development of ectodermal appendages. J. Cell. Physiol. 216: 337–346, 2008. © 2008 Wiley‐Liss, Inc.