Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy | Zendy

Giordano Antonio | Zendy; Rossi Alessandra | Zendy; Romano Gaetano | Zendy; Bagella Luigi | Zendy

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Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy

Author(s) -

Giordano Antonio,

Rossi Alessandra,

Romano Gaetano,

Bagella Luigi

Publication year - 2007

Publication title -

journal of cellular physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 174

eISSN - 1097-4652

pISSN - 0021-9541

DOI - 10.1002/jcp.21225

Subject(s) - retinoblastoma , suppressor , cancer research , tumor suppressor gene , gene , cell cycle , cancer , cell growth , biology , genetics , carcinogenesis

Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer domain in cancer treatment. J. Cell. Physiol. 213: 403–406, 2007. © 2007 Wiley‐Liss, Inc.

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