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Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy
Author(s) -
Giordano Antonio,
Rossi Alessandra,
Romano Gaetano,
Bagella Luigi
Publication year - 2007
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21225
Subject(s) - retinoblastoma , suppressor , cancer research , tumor suppressor gene , gene , cell cycle , cancer , cell growth , biology , genetics , carcinogenesis
Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer domain in cancer treatment. J. Cell. Physiol. 213: 403–406, 2007. © 2007 Wiley‐Liss, Inc.