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Ca 2+ signaling differentiation during oocyte maturation
Author(s) -
Machaca Khaled
Publication year - 2007
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21194
Subject(s) - oocyte activation , oocyte , microbiology and biotechnology , human fertilization , signal transduction , embryogenesis , biology , cellular differentiation , chemistry , embryo , biochemistry , genetics , gene
Abstract Oocyte maturation is an essential cellular differentiation pathway that prepares the egg for activation at fertilization leading to the initiation of embryogenesis. An integral attribute of oocyte maturation is the remodeling of Ca 2+ signaling pathways endowing the egg with the capacity to produce a specialized Ca 2+ transient at fertilization that is necessary and sufficient for egg activation. Consequently, mechanistic elucidation of Ca 2+ signaling differentiation during oocyte maturation is fundamental to our understanding of egg activation, and offers a glimpse into Ca 2+ signaling regulation during the cell cycle. J. Cell. Physiol. 213: 331–340, 2007. © 2007 Wiley‐Liss, Inc.