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The MET receptor tyrosine kinase in invasion and metastasis
Author(s) -
Benvenuti Silvia,
Comoglio Paolo M.
Publication year - 2007
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21183
Subject(s) - hepatocyte growth factor , anoikis , receptor tyrosine kinase , microbiology and biotechnology , receptor , tyrosine kinase , cell surface receptor , extracellular matrix , extracellular , hepatocyte growth factor receptor , biology , cancer cell , chemistry , kinase , signal transduction , cancer , biochemistry , c met , genetics
Abstract Various cytokines and soluble growth factors upon interaction with their membrane receptors are responsible for inducing cellular proliferation, differentiation, movement, and protection from anoikis (a planned suicide activated by normal cells in absence of attachment to neighboring cells or extracellular matrix (EMC)). Among those soluble factors a major position is exerted by hepatocyte growth factor (HGF) together with its receptor MET and macrophage‐stimulating protein (MSP) in cooperation with its receptor RON. J. Cell. Physiol. 213: 316–325, 2007. © 2007 Wiley‐Liss, Inc.