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Interplay between chromatin remodelers and protein arginine methyltransferases
Author(s) -
Pal Sharmistha,
Sif Saïd
Publication year - 2007
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21180
Subject(s) - chromatin remodeling , chromatin , histone methyltransferase , biology , histone modifying enzymes , methyltransferase , histone , histone methylation , microbiology and biotechnology , histone code , methylation , biochemistry , genetics , dna methylation , dna , gene expression , gene , nucleosome
Chromatin modifying enzymes have emerged as key regulators of all DNA based processes, which control cell growth, development, and differentiation. Recently, it has become clear that different chromatin remodeling and histone‐modifying activities are involved in transcriptional activation and repression. Among the enzymes involved in regulating chromatin structure is the family of protein arginine methyltransferases (PRMTs) that specializes in methylating both histones as well as key cellular proteins. There are eleven different PRMT genes (PRMT1‐11) whose biological function remains under explored. PRMTs regulate various cellular processes such as DNA repair and transcription, RNA processing, signal transduction, and nucleo‐cytoplasmic localization. Like histone lysine methylation, methylation of histone arginine residues can either induce or inhibit transcription depending on the residue being modified and the type of methylation being introduced. In this review, we will focus on the latest findings and biological roles of ATP‐dependent chromatin remodeling complexes and PRMT enzymes, and how their aberrant expression is linked to cancer. J. Cell. Physiol. 213: 306–315, 2007. © 2007 Wiley‐Liss, Inc.