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Liver regeneration
Author(s) -
Michalopoulos George K.
Publication year - 2007
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21172
Subject(s) - liver regeneration , regeneration (biology) , microbiology and biotechnology , regenerative process , homeostasis , biology , cell , cell growth , hepatectomy , organism , stimulation , cell type , stem cell , neuroscience , medicine , biochemistry , genetics , surgery , resection
Liver regeneration after partial hepatectomy is a very complex and well‐orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related signals. Liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process. In situations when hepatocytes or biliary cells are blocked from regeneration, these cell types can function as facultative stem cells for each other. J. Cell. Physiol. 213: 286–300, 2007. © 2007 Wiley‐Liss, Inc.