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Changes in chromosome positioning may contribute to the development of diseases related to X‐chromosome aneuploidy
Author(s) -
Petrova Natalia V,
Yakutenko Irina I.,
Alexeevski Andrei V.,
Verbovoy Valentin A.,
Razin Sergey V.,
Iarovaia Olga V.
Publication year - 2007
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.21118
Subject(s) - centromere , polysomy , biology , aneuploidy , chromosome , genetics , context (archaeology) , x chromosome , karyotype , gene , fluorescence in situ hybridization , paleontology
The radial positions of the centromeric regions of chromosomes 1 and X were determined in normal male fibroblasts (XY) and in fibroblasts from a patient with a rare case of XXXXY polysomy. The centromeric regions and presumably the whole territories of active X chromosomes were demonstrated to occupy similar, although not identical, positions in XY and XXXXY cells. The centromeres of inactive X chromosomes (Barr bodies) were located closer to the nuclear periphery as compared with the centromeres of active X chromosomes. In addition, it was established that the nuclear radial position of gene‐rich chromosome 1 was changed in XXXXY cells as compared to normal XY cells. The data are discussed in the context of the hypothesis postulating that changes in nuclear positioning of chromosomal territories induced by the presence of extra copies of individual chromosomes may contribute to the development of diseases related to different polysomies. J. Cell. Physiol. 213: 278–283, 2007. © 2007 Wiley‐Liss, Inc.