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Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis
Author(s) -
Vogiatzi Paraskevi,
Vindigni Carla,
Roviello Franco,
Renieri Alessandra,
Giordano Antonio
Publication year - 2007
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.20982
Subject(s) - epigenetics , malignancy , cancer , carcinogenesis , biology , stomach cancer , genetics , bioinformatics , cancer research , gene
Gastric cancer is a common aggressive malignancy. Although its incidence shows considerable variation among different countries, gastric cancer is still a major health problem worldwide. The causes of stomach cancer are not completely understood. What is clear is that gastric cancer is a multi‐stage process involving genetic and epigenetic factors. This review is an in‐depth study of the known genetic and epigenetic processes in the development of this tumor, and delineates possible approaches in gene and epigenetic therapy. J. Cell. Physiol. 211: 287–295, 2007. © 2007 Wiley‐Liss, Inc.