Premium
Cell senescence: Hypertrophic arrest beyond the restriction point
Author(s) -
Blagosklonny Mikhail V.
Publication year - 2006
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.20750
Subject(s) - senescence , restriction point , cell cycle checkpoint , cyclin , microbiology and biotechnology , g1 phase , cell growth , biology , cell cycle , cdk inhibitor , muscle hypertrophy , cell , cyclin dependent kinase , endocrinology , genetics
Withdrawal of mitogens (growth factors) arrests normal cells in G0 (quiescence). All other stresses and factors arrest cell cycle beyond the restriction point in G1 and G2 (non‐G0 arrest), in the presence of mitogenic stimulation. Strong mitogenic stimuli by themselves cause non‐G0 arrest. Unlike G0, arrest beyond restriction point is characterized by both high levels of cyclins and CDK inhibitors, activated mitogenic pathways with a secondary GF resistance, and continuous mass growth (cell hypertrophy). Prolonged hypertrophic arrest culminates in cell senescence. This review discusses that quiescence and senescence are two opposite, mutually exclusive conditions and that cell senescence can be reversed and prevented. J. Cell. Physiol. 209: 592–597, 2006. © 2006 Wiley‐Liss, Inc.