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MicroRNA: A new player in stem cells
Author(s) -
Zhang Baohong,
Pan Xiaoping,
Anderson Todd A.
Publication year - 2006
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.20713
Subject(s) - stem cell , microrna , biology , microbiology and biotechnology , computational biology , computer science , genetics , gene
microRNAs (miRNAs) are an abundant class of endogenous non‐protein‐coding small RNAs, which negatively regulate gene expression at the posttranscriptional level in many developmental and metabolic processes. miRNAs regulate a variety of biological processes, including developmental timing, signal transduction, tissue differentiation and maintenance, disease, and carcinogenesis. Emerging evidence demonstrates that miRNAs also play an essential role in stem cell self‐renewal and differentiation. Some miRNAs are specifically expressed in stem cells, control stem cell self‐renewal, and differentiation through negatively regulating the expression of certain key genes in stem cells. J. Cell. Physiol. 209: 266–269, 2006. © 2006 Wiley‐Liss, Inc.